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Merck

5.08159

Salvinorin A

Synonym(s):

Salvinorin A, κ-opioid Receptor Agonist, Salvinorin A, Divinorin A

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About This Item

Empirical Formula (Hill Notation):
C23H28O8
CAS Number:
83729-01-5
Molecular Weight:
432.46
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD05664742

Key Documents

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SMILES string

[o]1cc(cc1)[C@H]2OC(=O)[C@H]3[C@@]([C@@H]4[C@]([C@@H](C[C@@H](C4=O)OC(=O)C)C(=O)OC)(CC3)C)(C2)C

InChI

1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1

InChI key

OBSYBRPAKCASQB-AGQYDFLVSA-N

assay

≥98% (HPLC)

form

solid

potency

4.3 nM Ki

manufacturer/tradename

Calbiochem®

drug control

Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet

storage condition

OK to freeze
protect from light

color

white

solubility

ethanol: 10 mM
DMSO: 50 mM

storage temp.

−70°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Primary Target
k opioid receptor

Disclaimer

Toxicity: Standard Handling (A)

General description

A highly potent and selective non-alkaloid positive allosteric modulator of Κ-opioid receptors (Ki = 4.3 nM and 16 nM for native and cloned κ-opioid receptors, respectively). Also acts as a D2DR partial agonist (Ki = 5-10 nM). Used in studies of addition.

Other Notes

Roth, B. et al., 2002. PNAS.99, 11934.
Valdés III., j., et al., 1984. J. Organic Chem.49, 4716.
Ortega, A., et al., 1982. J. of Chem. Society, Perkins Transactions I. 2505.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

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