Pepstatin A

Name: Pepstatin A
Brand: MM

≥98% (HPLC), aspartic proteases inhibitor, liquid

Synonym(s):

InSolution Pepstatin A, Synthetic, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid, Pepstatin A, Synthetic InSolution, Pepstatin A, Synthetic InSolution, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid

Select a Size

All Photos(1)

About This Item

Empirical Formula (Hill Notation):

C₃₄H₆₃N₅O₉

CAS Number:

26305-03-3

Molecular Weight:

685.89

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00060740

Product Name

Pepstatin A, InSolution, ≥98%, Synthetic, protease inhibitor

SMILES string

N([C@@H](C(C)C)C(=O)NC(C(O)CC(=O)N[C@@H](C)C(=O)NC(C(O)CC(=O)O)CC(C)C)CC(C)C)C(=O)[C@@H](NC(=O)CC(C)C)C(C)C

InChI

1S/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23?,24?,25?,26?,30-,31-/m0/s1

InChI key

FAXGPCHRFPCXOO-JHTFMCFMSA-N

Quality Level

100

assay

≥98% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

storage temp.

−70°C

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Disclaimer

Toxicity: Standard Handling (A)

Other Notes

Isahara, K., et al. 1999. Neuroscience91, 233.
Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun.251, 204.
Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res.40, 233.

Carraway, R.E., et al. 1991. Peptides12, 107.
Eid, M., et al. 1981. Biochem. J.197, 465.
Umezawa, H., et al. 1970. J. Antibiot.23, 259.

Iva-Val-Val-Sta-Ala-Sta

Packaging

Packaged under inert gas

Physical form

A 25 mM (10 mg/583 µL) sterile-filtered solution of Pepstatin A, Synthetic (Cat. No. 516481-M) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 4 months at -20°C. Use only fresh DMSO for further dilutions.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Application

Pepstatin A has been used as a negative control in enzymatic activity assays to inhibit CTSD activity in lysosomal studies involving chondrocytes.

Features and Benefits

Primary Target: aspartic proteases
Reversible: yes

General description

Pepstatin A, a pentapeptide containing two non-proteinogenic statin residues, is a highly effective inhibitor of cathepsin D (CTSD). It also inhibits other aspartic proteases at nanomolar concentrations (with a Ki of 10-10 M). Pepstatin A is commonly utilized for mapping, purifying, or titrating CTSD. Pepstatin A is found to block the invasion of C. albicans into corneocytes in mice with cutaneous candidiasis and inhibit aspartyl proteases.

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - (refers to pure substance)

flash_point_c

87 °C - (refers to pure substance)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Global Trade Item Number

SKU	GTIN
5.08437.0001	04055977261967

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service