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Merck

5.08509

NS309

Synonym(s):

NS309, Ca2+ -activated K+ Channels Activator, NS309, NS-309, NS 309

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About This Item

Empirical Formula (Hill Notation):
C8H4Cl2N2O2
CAS Number:
18711-16-5
Molecular Weight:
231.04
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD06798346

Key Documents

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SMILES string

Clc1[c]2[c](ccc1Cl)=C(C(=O)N=2)NO

InChI

1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,14H,(H,11,12,13)

InChI key

CVOUSAVHMDXCKG-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 100 mM

storage temp.

−20°C

Quality Level

100

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General description

A potent activator of Ca2+ -activated K+ channels of SK and IK types but not BK type channels. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell. NS309 blocks L-type Calcium channels with IC50 = 10 µM/L. Recently, this compound has been shown to produce endothelium-dependent hyperpolarizations in guinea pig carodid arteries by opening KCa2.3 and KCa3.1 channels demonstrating a new therapeutic option for treating hypertension.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Primary Target
Ca2+-activated K+ channels

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Leurangue, V. et al. 2008. Naunyn Schmiedebergs Arch. Pharmacol.377, 101.
Morimura, K. et al. 2006. J. Pharmacol. Sci.100, 237.
Strobaek, D. et al. 2004. Biochim. Biophys. Acta.1665, 1.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
5.08509.000104055977262025

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