Key Documents

COA/COQ

5.08509

NS309

Name: NS309
Brand: MM

Synonym(s):

NS309, Ca2+ -activated K+ Channels Activator, NS309, NS-309, NS 309

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About This Item

Empirical Formula (Hill Notation):

C₈H₄Cl₂N₂O₂

CAS Number:

18711-16-5

Molecular Weight:

231.04

MDL number:

MFCD06798346

UNSPSC Code:

12352200

NACRES:

NA.77

Assay

≥98% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 100 mM

storage temp.

−20°C

SMILES string

Clc1[c]2[c](ccc1Cl)=C(C(=O)N=2)NO

InChI

1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,14H,(H,11,12,13)

InChI key

CVOUSAVHMDXCKG-UHFFFAOYSA-N

General description

A potent activator of Ca2+ -activated K+ channels of SK and IK types but not BK type channels. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell. NS309 blocks L-type Calcium channels with IC₅₀ = 10 µM/L. Recently, this compound has been shown to produce endothelium-dependent hyperpolarizations in guinea pig carodid arteries by opening KCa2.3 and KCa3.1 channels demonstrating a new therapeutic option for treating hypertension.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Primary Target
Ca2+-activated K+ channels

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Leurangue, V. et al. 2008. Naunyn Schmiedebergs Arch. Pharmacol.377, 101.
Morimura, K. et al. 2006. J. Pharmacol. Sci.100, 237.
Strobaek, D. et al. 2004. Biochim. Biophys. Acta.1665, 1.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKU	GTIN
5.08509.0001	04055977262025

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