5.08510
ZD 7288
Synonym(s):
ZD 7288, 4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino)pyrimidiniumchloride, Zeneca, HCN Channel Blocker, ZD 7288, ZD-7288, ZD7288
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About This Item
Empirical Formula (Hill Notation):
C15H21ClN4
CAS Number:
Molecular Weight:
292.81
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
assay
≥98% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
water: 100 mM
storage temp.
2-8°C
SMILES string
Cl.[n]1([c](cc(nc1C)N(CC)c2ccccc2)=NC)C
InChI
1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H
InChI key
DUWKUHWHTPRMAP-UHFFFAOYSA-N
General description
ZD7288 is a potent HCN blocker of hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) in heart and brain tissue. Recently shown to also block Na+ currents in DRG neurons and in HEK293 cells transfected with Na(v)1.4 plasmids. In voltage clamp experiments, it is shown to reduce Ih in a time- and concentration-dependent manner (IC50 = 2 mM). Suggested to behave as a lipophilic quaternary cation that can pass into the cell interior to block Ih channels in their closed state.
Biochem/physiol Actions
Primary Target
HCN channel
HCN channel
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Pleasenote that the molecular weight for this compound is batch-specific due tovariable water content.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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