5.08514
Psalmotoxin-1
Synonym(s):
Psalmotoxin-1, ASIC1a Inhibitor, Psalmotoxin 1
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About This Item
Empirical Formula (Hill Notation):
C200H312N62O57S6
CAS Number:
Molecular Weight:
4689.39
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥94% (HPLC)
Form:
semisolid, viscous liquid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
assay
≥94% (HPLC)
Quality Level
form
semisolid, viscous liquid
potency
0.9 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
colorless
storage temp.
−20°C
General description
A potent proton-gated sodium channel (ASIC1a) channel blocking neurotoxin (IC50 = 0.9 nm) isolated from the Trinidad chevron tarantula. Psalmotoxin-1 (PcTx1) can distinguish between the two ASIC1 splice variants, ASIC1a and ASIC1b. Binding site is blocked when dimerization with ASIC2a or ASIC3.
Biochem/physiol Actions
Primary Target
ASIC1a
ASIC1a
Other Notes
EDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (disulfide bond 3-18, 10-23, 17-33)
Qadri, Y. J. et al. 2009. J. Biol. Chem.284, 17625.
M. Mazzuca, et al. 2007. Nat Neurosci.10, 943.
Escoubas, P. et al. 2000. J. Biol. Chem.275, 25116.
M. Mazzuca, et al. 2007. Nat Neurosci.10, 943.
Escoubas, P. et al. 2000. J. Biol. Chem.275, 25116.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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