5.09106
Sphingosine Kinase-2 Inhibitor, K145
Synonym(s):
Sphingosine Kinase-2 Inhibitor, K145, SphK2 Inhibitor, K145
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About This Item
Empirical Formula (Hill Notation):
C18H24N2O3S
CAS Number:
Molecular Weight:
348.46
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥95% (HPLC)
form
powder
potency
4.3 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
DMSO: 100 mg/mL
water: 2.5 mg/mL
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Sphk2
Sphk2
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell permeable, orally bioavailable thiazolidine-2,4-dione derivative that acts as a selective, sphingosine competitive inhibitor of spingosine Kinase -2 (SphK2; IC50 = 4.3 µM; Ki = 6.4 µM), but does not affect the activities of sphingosine kinase-1, ceremide kinase, and ceramide synthase even at high concentration (~10 micro;M). Shown to inhibit the growth of U937 human leukemic monocyte lymphoma cells by inducing apoptosis and inhibiting the phosphorylation of ERK and Akt. Blocks the growth of U937 cells in nude mice and inhibits the growth of JC tumor cells in BALB/c mice without any apparent toxicity.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Other Notes
Liu, K., et al. 2013. PLos One8, e56471.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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