5.09884
Myristoylated-FEEERA, mP6
Synonym(s):
Myristoylated-FEEERA, mP6, Integrin Signaling Inhibitor I, mP6
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About This Item
Empirical Formula (Hill Notation):
C47H75N9O14
Molecular Weight:
990.15
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
white
solubility
DMSO: 100 mg/mL
storage temp.
−70°C
Quality Level
Related Categories
Biochem/physiol Actions
Cell permeable: yes
Primary Target
platelet integrin →IIb→3
platelet integrin →IIb→3
Reversible: yes
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable myristoylated hexapeptide derived from EXE-motif-containing integrin β3 subunit that selectively inhibits integrin outside-in signaling without affecting inside-out signaling . Shown to specifically block the interaction of Gα3 and integrin β3 subunit resulting in the inhibition of Gα13-dependent early phase outside-in signaling. Selectively inhibits thrombosis without affecting haemostasis.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Other Notes
FEEERA
Shen, B., et al. 2013. Nature503, 131.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-207deg;C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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