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512731

Paromomycin Sulfate

Name: Paromomycin Sulfate
Brand: MM

An aminoglycoside antibiotic containing 5 amino groups that exhibits antibacterial and antiamebic activity.

Synonym(s):

Paromomycin Sulfate, Neomycin E

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₄₅N₅O₁₄ · xH₂SO₄

CAS Number:

1263-89-4

Molecular Weight:

615.63 (free base basis)

UNSPSC Code:

12352200

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Properties

Quality Segment

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

off-white

solubility

water: soluble

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18?,19-,20-,21-,22-,23?;/m1./s1

InChI key

LJRDOKAZOAKLDU-UMIPPVEZSA-N

Description

General description

An aminoglycoside antibiotic containing 5 amino groups that exhibits antibacterial and antiamebic activity. Recent NMR evidence indicates that paromomycin binding to the A-site of 16S rRNA induces a local conformational change, suggesting a mechanism for aminoglycoside action on protein translation. Also exhibits anti-protozoal properties.

Potency: ≥675 µg/mg.

Other Notes

VanLoock, M.S., et al. 1999. J. Mol. Biol. 285, 2069.
Blanchard, S.C., et al. 1998. Biochemistry 37, 7716.
Fourmy, D., et al. 1998. J. Mol. Biol. 277, 333.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c