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Merck

513100

DL-threo-PDMP, Hydrochloride

PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and acts as a potent and competitive inhibitor of this enzyme.

Synonym(s):

DL-threo-PDMP, Hydrochloride, 1-Phenyl-2-decanoylamino-3-morpholino-1-propanol, HCl

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About This Item

Empirical Formula (Hill Notation):
C23H38N2O3 · xHCl
CAS Number:
80938-69-8
Molecular Weight:
390.56 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00236490
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze

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SMILES string

Cl.N2(CCOCC2)C[C@@H](NC(=O)CCCCCCCCC)[C@H](O)c1ccccc1

InChI

1S/C23H38N2O3.ClH/c1-2-3-4-5-6-7-11-14-22(26)24-21(19-25-15-17-28-18-16-25)23(27)20-12-9-8-10-13-20;/h8-10,12-13,21,23,27H,2-7,11,14-19H2,1H3,(H,24,26);1H/t21-,23-;/m1./s1

InChI key

HVJHJOYQTSEKPK-BLDCTAJRSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: soluble, ethanol: soluble, methanol: soluble

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

General description

PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and acts as a potent and competitive inhibitor of this enzyme. Blocks the outgrowth of neurites and inhibits glycolipid synthesis in cultured NIH/3T3 cells.

Biochem/physiol Actions

Cell permeable: no
Primary Target
glycolipid synthesis in cultured NIH/3T3 cells
Product does not compete with ATP.
Reversible: no

Other Notes

Rani, C.S., et al. 1995. J. Biol. Chem. 270, 2859.
Rosenwald, A.G. 1992. Biochemistry31, 3581.
Inokuchi, J., and Radin, N.S. 1987. J. Lipid Res.28, 565.
Vunnam, R.R., and Radin, N.S. 1980. Chem. Phys. Lipids26, 265.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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