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Merck

516561

Pertussis toxin

from Bordetella pertussis, Five distinct bands by SDS-PAGE, liquid, protein endotoxin, Calbiochem

Synonym(s):

Pertussis Toxin, Bordetella pertussis, Glycerol Solution

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About This Item

CAS Number:
70323-44-3
UNSPSC Code:
12352200
NACRES:
NA.25
MDL number:
MFCD00131841

Key Documents

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Product Name

Pertussis Toxin, Bordetella pertussis, Glycerol Solution, Pertussis Toxin, Bordetella pertussis, Glycerol Solution, CAS 70323-44-3, is a protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins.

SMILES string

O(C)C(=O)CCCCCCCCCCCCCCCCCCCCCCCC

InChI

1S/C26H52O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28-2/h3-25H2,1-2H3

InChI key

WOPKHAQDUMDJIY-UHFFFAOYSA-N

description

RTECS - XW5883750

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

shipped in

wet ice

storage temp.

−20°C

Quality Level

200

Related Categories

Analysis Note

Five distinct bands by SDS-PAGE

Biochem/physiol Actions

≤1 ng/ml as determined in a clustering assay using CHO cells line
Primary Target
Guanine nucleotide-binding regulatory proteins
Product does not compete with ATP.
Target IC50: ≤1 ng/ml as determined in a clustering assay using CHO cells line

Disclaimer

Toxicity: Toxic (F)

General description

A protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins. The holotoxin has five dissimilar subunits S-1, S-2, S-3, S-4, and S-5, in a molar ratio of 1:1:1:2:1, S-1 (A protomer) is responsible for the enzymatic activity of the toxin, and S-2, S-3, S-4, and S-5 form the B oligomer which is responsible for the toxins binding to the cell surface. NOTE: This product is not activated, hence for use in cell-free systems, activation is required.
Pertussis Toxin, Bordetella pertussis, Glycerol Solution, CAS 70323-44-3, is a protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Fryer, M.W. 1992. Neurosci. Lett.146, 84.
Gierschik, P. 1992. Curr. Topics Microbiol. Immunol.175, 69.
Harada, J., et al. 1992. Eur. J. Pharmacol.227, 301.
Hausman, S.Z., and Burns, D.L. 1992. J. Biol. Chem.267, 13735.
Kaslow, H.R., and Burns, D.L. 1992. FASEB J.6, 2684.
Zhu, J., et al. 1992. J. Pharmacol. Exp. Therap.263, 1479
Kaslow, H.R., et al. 1987. Biochemistry26, 123.
Hewlett, E.L., et al. 1983. Infect. Immun.40, 1198.
Moss, J., et al. 1983. J. Biol. Chem.258, 11879.

Physical form

In 500 mM NaCl, 50 mM Tris, 10 mM glycine, 50% glycerol, pH 7.5.

Preparation Note

A uniform suspension may be achieved by gentle mixing prior to use.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 2

Certificates of Analysis (COA)

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