516566
PPARγ Antagonist III, G3335
The PPARγ Antagonist III, G3335, also referenced under CAS 36099-95-3, controls the biological activity of PPARγ.
Synonym(s):
PPARγ Antagonist III, G3335, H-Trp-Glu-OH
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About This Item
Empirical Formula (Hill Notation):
C16H19N3O5
CAS Number:
Molecular Weight:
333.34
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (TLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
water: 30 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[nH]1c2c(c(c1)C[C@H](N)C(=O)N[C@@H](CCC(=O)O)C(=O)O)cccc2
InChI
1S/C16H19N3O5/c17-11(7-9-8-18-12-4-2-1-3-10(9)12)15(22)19-13(16(23)24)5-6-14(20)21/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/m0/s1
InChI key
PWIQCLSQVQBOQV-AAEUAGOBSA-N
General description
A cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist (KD = ~ 8 µM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC50 = 31.9 µM) in transfected COS-7 cells.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PPARγ
PPARγ
Product does not compete with ATP.
Reversible: yes
kd = ~ 8 µM as PPARγ antagonist
Packaging
Packaged under inert gas
Preparation Note
Addition of a small amount of acid or base may be required for complete solubilization.
Following reconstitution aliquot freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Ye, F., et al. 2006. Chembiochem7, 74.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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