516568
PPARβ/δ Inverse Agonist
The PPARβ/δ Inverse Agonist controls the biological activity of PPARβ/δ.
Synonym(s):
PPARβ/δ Inverse Agonist, methyl 3-(N-(4-(hexylamino)-2-methoxyphenyl)sulfamoyl)thiophene-2-carboxylate (ST247)
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About This Item
Empirical Formula (Hill Notation):
C19H26N2O5S2
Molecular Weight:
426.55
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 100 mg/mL, clear, amber-yellow
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable, diaryl sulfonamide inverse agonist that demonstrates selectivity for the ligand-binding domain of the PPAR β/δ receptor (IC50 = 93 nM). Enhances the interaction of the PPARβ/δ ligand-binding domain with the co-repressor, SMRT-ID2 (EC50 = 10 nM). Down-regulates the peroxisome proliferator response elements (PPREs)-driven target gene, ANGPTL4. Inhibits PPARβ/δ- specific agonist-induced transcriptional activity in human myofibroblasts and mouse thioglycollate-elicited peritoneal macrophages.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Naruhn, S., et al. 2011., Mol Pharmacol.80, 828.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
Certificates of Analysis (COA)
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