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Merck

516569

PPARβ/δ Antagonist, PT-S58

The PPARβ/δ Antagonist, PT-S58 controls the biological activity of PPARβ/δ.

Synonym(s):

PPARβ/δ Antagonist, PT-S58, PPARβ Antagonist II, methyl 3-(N-(4-(tert-butylamino)-2-methoxyphenyl)sulfamoyl)thiophene-2-carboxylate, PPARδ Antagonist II

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About This Item

Empirical Formula (Hill Notation):
C17H22N2O5S2
Molecular Weight:
398.50
UNSPSC Code:
12352200
MDL number:
MFCD22666395
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

dark yellow

solubility

DMSO: 100 mg/mL, clear, amber-yellow

shipped in

ambient

storage temp.

−20°C

Quality Level

100

General description

A cell-permeable, diaryl sulfonamide PPARβ/δ subtype-specific pure competitive antagonist with an IC50 of 98 nM. Antagonizes ligand binding without enabling coregulator interactions. Inhibits the PPARβ/δ specific agonist-induced transcriptional activity in cell cultures.

Packaging

Packaged under inert gas

Other Notes

Naruhn, S., et al. 2011, Mol. Pharm.80, 828.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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