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520219

PPACK II trifluoroacetate salt

Name: PPACK II trifluoroacetate salt
Brand: MM

≥95% (HPLC), solid, kallikrein inhibitor, Calbiochem^®

Synonym(s):

PPACK II, Trifluoroacetate Salt

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About This Item

Empirical Formula (Hill Notation):

C₂₅H₃₃ClN₆O₃ · 2C₂HF₃O₂

CAS Number:

74392-49-7

Molecular Weight:

729.07

MDL number:

MFCD03788124

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, desiccated

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Properties

Product Name

PPACK II, Trifluoroacetate Salt, Potent and specific irreversible inhibitor of plasma and glandular kallikreins.

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated

color

off-white

solubility

water: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

ClCC(=O)[C@@H](N[C@@H](Cc2ccccc2)C(=O)NC(=O)[C@H](N)Cc1ccccc1)CCCNC(=N)N

InChI

1S/C25H33ClN6O3/c26-16-22(33)20(12-7-13-30-25(28)29)31-21(15-18-10-5-2-6-11-18)24(35)32-23(34)19(27)14-17-8-3-1-4-9-17/h1-6,8-11,19-21,31H,7,12-16,27H2,(H4,28,29,30)(H,32,34,35)/t19-,20+,21+/m1/s1

InChI key

UFXAQJOOAQICNE-HKBOAZHASA-N

Description

General description

Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Inhibits the cleavage of atrial naturiuretic peptide (ANP 1-126) by kallikreins. Also inhibits adrenal kininogenase, a kallikrein-like enzyme. Also available as a 10 mM solution in H2O.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Plasma and glandular kallikreins

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Other Notes

Byrne, R.E., and Scanu, A.M. 1989. J. Lipid Res. 30, 109.
Scicli, G., et al. 1989. Adv. Exp. Med. Biol.247B, 217.
Gibson, T.R., et al. 1987. Endocrinology120, 764.
Kettner, G., and Shaw, E. 1981. Methods Enzymol.80, 826.

H-D-Phe-Phe-Arg-chloromethylketone, 2TFA

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c