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523350

Sigma-Aldrich

PTIO

≥98% (titration), Nitric oxide radical scavenger, solid

Synonym(s):

PTIO, 2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide

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About This Item

Empirical Formula (Hill Notation):
C13H17N2O2
CAS Number:
18390-00-6
Molecular Weight:
233.29
MDL number:
MFCD00059929
UNSPSC Code:
12352200
NACRES:
NA.77

Product Name

PTIO, Nitric oxide radical scavenger.

Quality Level

100

Assay

≥98% (titration)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

dark blue

solubility

ethanol: soluble
water: soluble

shipped in

ambient

storage temp.

−20°C

SMILES string

[N+]1(=C([NH](=O)C(C1(C)C)(C)C)c2ccccc2)[O-]

InChI

1S/C13H17N2O2/c1-12(2)13(3,4)15(17)11(14(12)16)10-8-6-5-7-9-10/h5-9H,1-4H3

InChI key

DYUUGILMVYJEHY-UHFFFAOYSA-N

Related Categories

General description

Nitric oxide radical scavenger. Reacts with nitric oxide in a stoichiometric manner without affecting nitric oxide synthase activity. Inhibits the enhanced vascular permeability in solid tumors.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Nitric oxide radical scavenger
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

Other Notes

Hogg, N., et al. 1995. Free Radic. Res. 22, 47.
Maeda, H., et al. 1994. Jpn. J. Cancer Res.85, 331.
Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun.202, 923.
Akaike, T., et al. 1993. Biochemistry32, 827.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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