524618
PIP3 Antagonist, PITenin-7
The PIP3 Antagonist, PITenin-7 controls the biological activity of PIP3.
Synonym(s):
PIP3 Antagonist, PITenin-7, N-(4-Hydroxybiphenyl-3-ylcarbamothioyl)-3,5-dimethylbenzamide, Phosphatidylinositol-3,4,5-triphosphate Antagonist, PITenin-7, PIT-7, Akt Inhibitor XX, PDK1 Inhibitor V
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About This Item
Empirical Formula (Hill Notation):
C22H20N2O2S
CAS Number:
Molecular Weight:
376.47
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
semisolid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥95% (HPLC)
form
semisolid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow-white
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable DM-PIT-1 (Cat. No. 524619) analog that is more selective and potent than DM-PIT-1 against PH domain-mediated PIP3 (Cat. No. 524615) binding to Akt1 (IC50 = 13.4 and 27.1 µM, respectively) and PDK1 (IC50 = 52.3 and 80.5 µM, respectively), while being much less active than DM-PIT-1 against PIP3 GRP1 PH domain binding (12% vs 84% inhibition with 100 µM respective compound). PIT-7 is also shown to be more effective than DM-PIT-1 in inhibiting human glioblastoma U87MG survival (IC50 = 6.6 vs. 33.9 µM, respectively) and cellular Akt Ser473 phosphorylation in cultures in vitro.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Miao, B., et al. 2010. Proc. Natl. Acad. Sci. USA107, 20126.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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