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528105

Picrotoxin, Anamirta cocculin

Name: Picrotoxin, <i>Anamirta cocculin</i>
Brand: MM

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system.

Synonym(s):

Picrotoxin, Anamirta cocculin

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₈O₇ · C₁₅H₁₆O₆

CAS Number:

124-87-8

Molecular Weight:

602.58

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00074824

Assay:

≥94% (mixture of Picrotoxin and picrotin, HPLC)

Form:

crystals, powder

Storage condition:

OK to freeze

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Properties

Quality Segment

100

description

Merck USA index - 14, 7415

assay

≥94% (mixture of Picrotoxin and picrotin, HPLC)

form

crystals, powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white to light yellow

solubility

aqueous base: 3 mg/mL, ethanol: 50 mg/mL

shipped in

ambient

storage temp.

10-30°C

SMILES string

O6[C@]87[C@H]6C[C@@]9([C@]8([C@H](OC7=O)C%10OC(=O)C9[C@@H]%10C(O)(C)C)C)O.O1[C@]32[C@@]4([C@H](OC3=O)C5OC(=O)C([C@@]4(CC21)O)[C@@H]5C(=C)C)C

InChI

1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-3H3/t5-,6+,7?,8?,9-,13-,14-,15+;6?,7-,8?,9?,10+,13+,14+,15-/m10/s1

InChI key

VJKUPQSHOVKBCO-ZTYBEOBUSA-N

Description

General description

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system. Inhibits ³⁵S-TBPS binding to the Cl^– channel (IC₅₀ = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.

Biochem/physiol Actions

Primary Target
GABA receptors

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 240 nM against GABA receptors

Cell permeable: no

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Qian, H., and Dowling, J.E. 1994. J. Neurosci. 14, 4299.
Yoon, K.W., et al. 1993. J. Physiol.464, 423.
Akaike, N., et al. 1985. Experientia41, 70.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic (H)

pictograms

GHS06

signalword

Danger

hcodes

H300

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c