528112
PI 3-Kγ/CKII Inhibitor
Synonym(s):
PI 3-Kγ/CKII Inhibitor
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About This Item
Linear Formula:
C14H8FNO4S
CAS Number:
MDL number:
NACRES:
NA.28
UNSPSC Code:
12352202
Form:
(Yellow solid)
Storage condition:
OK to freeze
form
(Yellow solid)
Quality Segment
storage condition
OK to freeze
solubility
soluble (DMSO (20 mg/ml))
storage temp.
2-8°C
General description
A cell-permeable furanyl-thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor of PI 3-Kγ and CKII (IC50 = 20 nM). It inhibits other PI 3-K isotypes (IC50 = 0.94, 20, and 20 µM for α, β, δ, respectively) and MKK7β (IC50 >10 µM) only at much higher concentrations and exhibits little activity against 77 other commonly studied kinases even at concentrations as high as 10 µM. Shown to inhibit stimulated Akt phosphorylation in cells in vitro and offer blockage of thioglycollate-induced neutrophil recruitment in a murine peritonitis model in vivo.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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