528113
PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem
The PI 3-Kβ Inhibitor VI, TGX-221, also referenced under CAS 663619-89-4, controls the biological activity of PI 3-Kβ. This small molecule/inhibitor is primarily used for Cell Signaling applications.
Synonym(s):
PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem, (±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one, PI 3-K Inhibitor VI
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About This Item
Empirical Formula (Hill Notation):
C21H24N4O2
CAS Number:
Molecular Weight:
364.44
UNSPSC Code:
12352200
Quality Segment
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 10 mg/mL, ethanol: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable morpholino-pyrimidinone compound that acts as a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-Kβ (IC50 = 0.005, 0.1, 5, and ≥3.5 µM for -β, -δ, -α and -γ isoforms, respectively) with little activity against a panel of 15 commonly studied protein kinases even at concentrations as high as 10.0 µM. An excellent tool for studying p110β-dependent responses both in cells in vitro and in animals in vivo.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PI 3-Kβ
PI 3-Kβ
Product competes with ATP.
Reversible: yes
Target IC50: 0.005, 0.1, 5, and ≥3.5 µM for -β, -δ, -α and -γ isoforms, respectively
Packaging
Packaged under inert gas
Other Notes
Chaussade, C., et al. 2007. Biochem. J.404, 449.
Cosemans, J.M, et al. 2006. Blood108, 3045.
Condliffe, A.M., et al. 2005. Blood106, 1432.
Jackson, S.P., et al. 2005. Nat. Med.11, 507.
Cosemans, J.M, et al. 2006. Blood108, 3045.
Condliffe, A.M., et al. 2005. Blood106, 1432.
Jackson, S.P., et al. 2005. Nat. Med.11, 507.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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