528114
PI 3-Kγ Inhibitor VII
The PI 3-Kγ Inhibitor VII, also referenced under CAS 6318-41-8, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
PI 3-Kγ Inhibitor VII, 5-(Benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, AS041164, PI 3-K Inhibitor VII
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C11H7NO4S
CAS Number:
Molecular Weight:
249.24
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 40 mg/mL
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C11H7NO4S/c13-10-9(17-11(14)12-10)4-6-1-2-7-8(3-6)16-5-15-7/h1-4H,5H2,(H,12,13,14)/b9-4+
InChI key
SDGWAUUPHUBJNQ-RUDMXATFSA-N
General description
A cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive, and isoform-selctive PI 3-K inhibitor (IC50 = 0.07, 0.24, 1.45, and 1.70 M for the γ, α, β, and δ isoform, respectively) with little or no activity against a panel of 38 other commonly studied kinases (<20% inhibition at 1.0 M). Exhibits similar pharmacokinetics as LY 294002 in blocking rhRNATES-induced neutrophil peritoneal recruitment in mice in vivo. Also reported to exhibit significant in vivo prophylactic efficacy against carrageenan-induced tissue swelling in a rat paw edema model (100 mg/kg, p.o.).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Ferrandi, C., et al. 2007. J. Pharmacol. Exp. Ther.322, 923.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.