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Merck

528114

PI 3-Kγ Inhibitor VII

The PI 3-Kγ Inhibitor VII, also referenced under CAS 6318-41-8, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

PI 3-Kγ Inhibitor VII, 5-(Benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, AS041164, PI 3-K Inhibitor VII

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About This Item

Empirical Formula (Hill Notation):
C11H7NO4S
CAS Number:
6318-41-8
Molecular Weight:
249.24
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

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InChI key

SDGWAUUPHUBJNQ-RUDMXATFSA-N

InChI

1S/C11H7NO4S/c13-10-9(17-11(14)12-10)4-6-1-2-7-8(3-6)16-5-15-7/h1-4H,5H2,(H,12,13,14)/b9-4+

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 40 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

General description

A cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive, and isoform-selctive PI 3-K inhibitor (IC50 = 0.07, 0.24, 1.45, and 1.70 M for the γ, α, β, and δ isoform, respectively) with little or no activity against a panel of 38 other commonly studied kinases (<20% inhibition at 1.0 M). Exhibits similar pharmacokinetics as LY 294002 in blocking rhRNATES-induced neutrophil peritoneal recruitment in mice in vivo. Also reported to exhibit significant in vivo prophylactic efficacy against carrageenan-induced tissue swelling in a rat paw edema model (100 mg/kg, p.o.).

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Ferrandi, C., et al. 2007. J. Pharmacol. Exp. Ther.322, 923.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Chiara Ferrandi et al.
The Journal of pharmacology and experimental therapeutics, 322(3), 923-930 (2007-05-29)
Leukocyte trafficking to inflammatory sites is a gradual process, which is dominated in its early phases by chemokine- and cytokine-mediated neutrophil recruitment. The chemokine regulated on activation normal T cell expressed and secreted (RANTES) has been shown to be highly

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