Skip to Content
Merck

528208

Plasminogen Activator Inhibitor-1, Mutant

from Recombinant, ≥95% (SDS-PAGE), liquid, PAI-1 inhibitor, Calbiochem®

Synonym(s):

PAI-1, Mutant

Sign In to View Organizational & Contract Pricing.

Select a Size

All Photos(1)

About This Item

UNSPSC Code:
12352200
NACRES:
NA.77

Product Name

Plasminogen Activator Inhibitor-1, Mutant, Human, Recombinant, The Plasminogen Activator Inhibitor-1, Mutant, Human, Recombinant controls the biological activity of Plasminogen Activator. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

assay

≥95% (SDS-PAGE)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

shipped in

wet ice

storage temp.

−70°C

Quality Level

100

Biochem/physiol Actions

Reversible: no
Target Ki: 5.1 x 106 M-1 sec-1, 7.9 x 105 M-1 sec-1 against uPA and tPA, respectively
Cell permeable: no
Primary Target
Plasminogen Activator
Product does not compete with ATP.

Disclaimer

Toxicity: Standard Handling (A)

General description

Highly purified preparation of an altered form of human PAI-1 containing four mutated amino acids. Mutant PAI-1 is virtually unable to go latent and is stable at elevated temperature and pH for extended periods of time (t½ = 145 hours at 37°C, pH 7.4). Inhibits uPA (Ki = 5.1 x 106 M-1 sec-1) and tPA (Ki = 7.9 x 105 M-1 sec-1).

Other Notes

Berkenpas, M.B., et al. 1995. EMBO J. 14, 2969.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In 100 mM NaCl, 50 mM sodium phosphate buffer, 1 mM EDTA, pH 6.6.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

C Bouarab et al.
Molecular psychiatry, 26(9), 4968-4981 (2021-01-30)
Moderate stress increases memory and facilitates adaptation. In contrast, intense stress can induce pathological memories as observed in post-traumatic stress disorders (PTSD). A shift in the balance between the expression of tPA and PAI-1 proteins is responsible for this transition.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service