528281
Polo-like Kinase Inhibitor IV, SBE13
The Polo-like Kinase Inhibitor IV, SBE13, also referenced under CAS 775294-82-1, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
Polo-like Kinase Inhibitor IV, SBE13, N-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C24H27ClN2O4
CAS Number:
Molecular Weight:
442.94
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥94% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
assay
≥94% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
beige
solubility
DMSO: 25 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Related Categories
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable vanillin-derived pyridyl-ethanamine compound that acts as a highly potent type II Plk1 inhibitor (IC50 of 200 pM) and targets the less conserved DFG motif that is only accessible when the kinase is in its inactive DFG-out conformation, resulting in an excellent selectivity over Plk2 (IC50 >66 µM), Plk3 (IC50 = 875 nM), and aurora A kinase (no detectable effect). Shown to inhibit the proliferation of HeLa cells with an EC50 of 18 µM.
Other Notes
Keppner, S., et al. 2009. ChemMedChem.4, 1806.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service