PARP Inhibitor XII

Name: PARP Inhibitor XII
Brand: MM

The PARP Inhibitor XII, also referenced under CAS 489457-67-2, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

Synonym(s):

PARP Inhibitor XII, 3-(4-Chlorophenyl)quinoxaline-5-carboxamide

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₀ClN₃O

CAS Number:

489457-67-2

Molecular Weight:

283.71

MDL number:

MFCD11856053

UNSPSC Code:

12352200

NACRES:

NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

light brown

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Clc1ccc(cc1)c2nc3c(nc2)cccc3C(=O)N

InChI

1S/C15H10ClN3O/c16-10-6-4-9(5-7-10)13-8-18-12-3-1-2-11(15(17)20)14(12)19-13/h1-8H,(H2,17,20)

InChI key

FLYGLPYJEQPCFY-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

General description

A potent quinoxaline-based PARP inhibitor with a ~5-fold selectivity towards PARP-2 over PARP-1 (IC₅₀ = 7 and 33 nM, respectively). Reported to be brain-permeant and exhibit good pharmacokinetics.

Packaging

Packaged under inert gas

Other Notes

Ishida, J., et al. 2006. Bioorg. Med. Chem.14, 1378.
Iwashita, A., et al. 2005. FEBS Lett.579, 1389.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)