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Merck

528822

PARP Inhibitor XII

The PARP Inhibitor XII, also referenced under CAS 489457-67-2, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

Synonym(s):

PARP Inhibitor XII, 3-(4-Chlorophenyl)quinoxaline-5-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C15H10ClN3O
CAS Number:
Molecular Weight:
283.71
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze
protect from light
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Product Name

PARP Inhibitor XII, The PARP Inhibitor XII, also referenced under CAS 489457-67-2, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

InChI key

FLYGLPYJEQPCFY-UHFFFAOYSA-N

InChI

1S/C15H10ClN3O/c16-10-6-4-9(5-7-10)13-8-18-12-3-1-2-11(15(17)20)14(12)19-13/h1-8H,(H2,17,20)

SMILES string

Clc1ccc(cc1)c2nc3c(nc2)cccc3C(=O)N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

light brown

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

Disclaimer

Toxicity: Irritant (B)

General description

A potent quinoxaline-based PARP inhibitor with a ~5-fold selectivity towards PARP-2 over PARP-1 (IC50 = 7 and 33 nM, respectively). Reported to be brain-permeant and exhibit good pharmacokinetics.

Other Notes

Ishida, J., et al. 2006. Bioorg. Med. Chem.14, 1378.
Iwashita, A., et al. 2005. FEBS Lett.579, 1389.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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