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Merck

528825

PARP Inhibitor XV, UPF-1035

The PARP Inhibitor XV, UPF-1035, also referenced under CAS 370872-09-6, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

Synonym(s):

PARP Inhibitor XV, UPF-1035, 5-Benzoyloxyisoquinolin-1(2H)-one

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About This Item

Empirical Formula (Hill Notation):
C16H11NO3
CAS Number:
370872-09-6
Molecular Weight:
265.26
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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InChI key

FFWUPFYTTMMSTH-UHFFFAOYSA-N

InChI

1S/C16H11NO3/c18-15-13-7-4-8-14(12(13)9-10-17-15)20-16(19)11-5-2-1-3-6-11/h1-10H,(H,17,18)

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

pale beige

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

General description

A cell-permeable isoquinolinone compound that acts as an NAD+-binding site-targeting, PARP-2-selective inhibitor (IC50 against murine PARP-2 and bovine PARP-1 = 0.15 and 8.0 µM, respectively). Reported to preferentially inhibit PARP activity in nuclear extracts derived from PARP-1-/- over PARP-1+/+ murine fibroblasts (by 80% and 15%, respectively, at 10 µM), while exhibiting little effect against tankyrase-1-dependent mitotic spindle formation in HeLa cells even at concentrations as high as 100 µM.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Moroni, F., et al. 2009. Br. J. Pharmacol.157, 854.
Pellicciari, R., et al. 2008. ChemMedChem3, 914.
Soluble in DMSO ( mg/ml), aliquot & store at -20*C; stable for 6 months.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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