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Merck

528884

Polo-like Kinase Inhibitor V, Poloxin

The Polo-like Kinase Inhibitor V, Poloxin, also referenced under CAS 321688-88-4, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

Polo-like Kinase Inhibitor V, Poloxin, Polo-like Kinase Inhibitor V, 2-isopropyl-5-methyl-4-(2-methylbenzoyloxyimino)cyclohexa-2,5-dienone

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About This Item

Empirical Formula (Hill Notation):
C18H19NO3
CAS Number:
321688-88-4
Molecular Weight:
297.35
UNSPSC Code:
12352200
MDL number:
MFCD00534351
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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InChI

1S/C18H19NO3/c1-11(2)15-10-16(13(4)9-17(15)20)19-22-18(21)14-8-6-5-7-12(14)3/h5-11H,1-4H3/b19-16-

InChI key

CMOJHDQJJPIVEC-MNDPQUGUSA-N

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 25 mg/mL, clear, yellow

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

General description

A thymoquinone derivative, non-ATP competitive Polo-like Kinase 1 (Plk1) inhibitor specifically targeting the polo-box domain (PBD) of Plk1 (IC50) = 4.8 µM. Reduces both chromosome and kinetochoral localization of Plk1, induces chromosome congression defects , mitotic arrest in prometaphase, and apoptosis in HeLa cells at 25 µM. Exhibits anti-proliferative effects in a range of cancer cell lines, and in a mouse Xenograft model involving HeLa and MDA-MB-231 cells at 40 mg/kg.

Other Notes

Reindl, W., et al. 2008. Chem Biol.15, 459.
Yuan, J., et al. 2011, Am J Pathol179, 2091.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

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Sol-Bi Shin et al.
Journal of cellular physiology, 230(12), 3057-3067 (2015-05-16)
The expression of polo-like kinase 1 (Plk1) correlates with malignancy and is thus recognized as a target for cancer therapy. In addition to the development of ATP-competitive Plk1 inhibitors, the polo-box domain (PBD), a unique functional domain of PLKs, is

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