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529505

PON1 Activator, ZNPA

Name: PON1 Activator, ZNPA
Brand: MM

The PON1 Activator, ZNPA modulates the biological activity of PON1. This small molecule/inhibitor is primarily used for Biochemicals applications.

Synonym(s):

PON1 Activator, ZNPA, (Z)-2,3-bis (4-nitrophenyl)-acrylonitrile

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₉N₃O₄

CAS Number:

42172-66-7

Molecular Weight:

295.25

UNSPSC Code:

41106609

NACRES:

NA.77

Quality Level

100

Assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

pale yellow

solubility

DMSO: 25 mg/mL, pale yellow

shipped in

ambient

storage temp.

−20°C

SMILES string

N#C/C(C1=CC=C(C=C1)[N+]([O-])=O)=C\C2=CC=C(C=C2)[N+]([O-])=O

InChI

1S/C15H9N3O4/c16-10-13(12-3-7-15(8-4-12)18(21)22)9-11-1-5-14(6-2-11)17(19)20/h1-9H/b13-9+

InChI key

QPMLLJYCAKQATA-UKTHLTGXSA-N

General description

A cell-permeable stilbene derivative that serves as an aryl hydrocarbon receptor (AhR) ligand and acts as a highly specific and potent inducer of paraoxonase 1 (PON1). Shown to be a better activator of PON1 mRNA (EC₅₀ = 1 µM) and inducer of PON1 enzymatic activity (>3 fold at 5 µM) when compared to resveratrol (Cat. No. 554325). However, it is devoid of any activity against estrogen receptors and is not shown to inhibit activity of tyrosine kinases. Also shown to antagonize the effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) on cytochrome P450 1A1 (CYP1A1).

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Guyot, E., et al. 2011. Biochem. Pharm. 83, 627.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)