530006
Prion Protein, His•Tag®, Human, Recombinant, E. coli
Synonym(s):
rhPrP c, rhPrPc
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
Form:
liquid
Assay:
≥95% (SDS-PAGE)
assay
≥95% (SDS-PAGE)
Quality Level
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles
shipped in
wet ice
storage temp.
−20°C
General description
Recombinant, human prion protein (amino acids 23-231) fused to a His•Tag sequence and expressed in E. coli. Prion diseases or transmissible spongiform encephalopathies are neurodegenerative diseases that affect both humans and animals. All prion diseases share the same molecular pathogenic mechanism that involves conversion of normal cellular prion protein (PrPc) into a form that is insoluble in non-ionic detergent and partially resistant to proteases (PrPsc). Useful as an antigen standard in immunochemical detection of Creutzfeldt-Jakob Disease (CJD).
Physical form
In 10 mM sodium acetate, pH 4.0.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Calzolai, L., and Zahn, R. 2003. J. Biol. Chem.278, 35592.
Prusiner, S.B. 1998. Proc. Natl. Acad. Sci. USA95, 13363.
Swietnicki, W., et al. 1997. J. Biol. Chem.272, 27517.
Pan, K.M., et al. 1993. Proc. Natl. Acad. Sci. USA90, 10962.
Basler, K., et al. 1986. Cell46, 417.
Prusiner, S.B. 1998. Proc. Natl. Acad. Sci. USA95, 13363.
Swietnicki, W., et al. 1997. J. Biol. Chem.272, 27517.
Pan, K.M., et al. 1993. Proc. Natl. Acad. Sci. USA90, 10962.
Basler, K., et al. 1986. Cell46, 417.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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