530007
Prionogenesis inhibitor, DAPH-12
The Prionogenesis inhibitor, DAPH-12, also referenced under CAS 145915-63-5, blocks the de novo fibrillization process and disassembling preformed NM fibers. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
Synonym(s):
Prionogenesis inhibitor, DAPH-12, Aβ42 Amyloidogenesis Inhibitor
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About This Item
Empirical Formula (Hill Notation):
C22H19N3O4
CAS Number:
Molecular Weight:
389.40
UNSPSC Code:
12352200
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
orange
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
General description
A cell-permeable 4,5-dianilinophthalimide that antagonizes Aβ42 amyloidogenesis as well as yeast Sup35 N-terminal domain- (aa 1 -124; NM) mediated prionogenesis by blocking the de novo fibrillization process and disassembling preformed NM fibers. Treatment with DAPH-12 greatly reduces the ratio between prion-harboring ([PSI+]) and non-prion-harboring ([psi-]) yeast populations. DAPH-12 is also shown to effectively convert the [PSI+] phenotype into that of [psi-] in a dose-dependent manner, while exhibiting no activity against [RNQ+] prion-containing cells. While DAPH-12 is in general more effective than EGCG (Cat. No. 324880 ) in antagonizing the various forms of NM prions both in cell-free and cell-based system, these two reagents used in tandem can create a synergistic effect against antiprion activity.
Other Notes
Roberts, B.E., et al. 2009. Nat. Chem. Bio.5, 936.
Wang, H., et al. 2008. Proc. Natl. Acad. Sci. USA105, 7159.
Wang, H., et al. 2008. Proc. Natl. Acad. Sci. USA105, 7159.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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