5.30409
TLR8 Agonist, cpd14b
Synonym(s):
TLR8 Agonist, cpd14b, Toll-Like Receptor 8 Agonist
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About This Item
Empirical Formula (Hill Notation):
C14H18N2
CAS Number:
Molecular Weight:
214.31
NACRES:
NA.77
UNSPSC Code:
51111800
assay
≥98% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 100 mg/mL
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Primary Target
TLR8
TLR8
Reversible: yes
Cell permeable: yes
Disclaimer
Toxicity: Standard Handling (A)
General description
A pentyl-quinoline derived compound that acts as a pure, potent agonist of Toll-like receptor 8 agonist (TLR8, EC50 = 200 nM in a human TLR8-specifc reporter gene assay). Does not affect TLR2, 3, 4, 5, 7, 9, 10, Nod1 and Nod2, and is devoid of any TLR7 activity. Shown to induce activities of several cytokines and chemokines, including IL-1a, IL-1b, IL-6, IL-8, IL-10, IL12, IL-18, IFN-g, CCL20, RANTES, GRO, GM-CSF, and Eotaxin (~ 10 mg/ml).
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Other Notes
Kokatla, H. P., et al. 2014, ChemMedChem9, 719.
Packaging
Packaged under inert gas
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 5.30409.0001 | 04055977260793 |
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