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Merck

5.30748

SRT1720 HCl

InSolution, ≥98%, 25 mM in DMSO

Synonym(s):

InSolution SRT1720, HCl, N-(2-(3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-quinolinecarboxamide, 4HCl;, Histone Acetyltransferase Inhibitor XI, p300/CBP Inhibitor IX, SRT1720, HCl InSolution, HAT Inhibitor XI, SIRT3 Inhibitor II, Sirtuin-3 In

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About This Item

Empirical Formula (Hill Notation):
C25H23N7OS · xHCl
MDL number:
MFCD18074509
UNSPSC Code:
12352200
NACRES:
NA.77

Product Name

SRT1720 HCl, InSolution, ≥98%, 25 mM in DMSO

SMILES string

[s]1c2[n](c(c1)CN6CCNCC6)cc(n2)c3c(cccc3)NC(=O)c4nc5c(nc4)cccc5.Cl

InChI

1S/C25H23N7OS.ClH/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31;/h1-8,13,15-16,26H,9-12,14H2,(H,29,33);1H

InChI key

DTGRRMPPXCRRIM-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

storage temp.

−70°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: yes
Primary Target
SIRT3
Reversible: yes
Secondary Target
p300 HAT

Disclaimer

Toxicity: Standard Handling (A)

General description

An enhanced aqueous soluble version of SRT1720 (Cat. No. 567860 ).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Other Notes

Baur, J.A., et al. 2012. Nat. Rev. Drug Discov.11, 443.
Minor, R.K., et al. 2011. Sci. Rep.1, 70.

Huber, J.L., et al. 2010. Future Med. Chem.2, 1751.
Pacholec, M., et al. 2010. J. Biol. Chem.285, 8340.
Jin, L., et al. 2009. Protein Sci.18, 514.
Feige, J.N., et al. 2008. Cell Metab.8, 347.
Milne, J.C., et al. 2007. Nature450, 712.

Packaging

Packaged under inert gas

Physical form

A 25 mM (10 mg/650 µl) sterile-filtered solution of SRT1720, HCl (Cat. No. 567860 ) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

188.6 °F

flash_point_c

87 °C

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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