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538916

16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem

A cell-permeable and orally available synthetic PGE2.

Synonym(s):

16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem

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About This Item

Empirical Formula (Hill Notation):
C22H36O5
CAS Number:
39746-25-3
Molecular Weight:
380.52
UNSPSC Code:
12352200
MDL number:
MFCD00151141
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assay

≥95% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

solubility

DMSO: 100 mg/mL, ethanol: 100 mg/mL, PBS, pH 7.2: 5 mg/mL

shipped in

wet ice

storage temp.

−70°C

InChI

1S/C22H36O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-17,19-20,24-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6+,13-12+/t16-,17?,19-,20+/m0/s1

InChI key

QAOBBBBDJSWHMU-BKSAQPBESA-N

General description

A cell-permeable and orally available synthetic PGE2.
A cell-permeable and orally available synthetic PGE2 (Cat. No. 538904 ) 16,16-dimethyl derivative that exhibits similar biological activity as PGE2 as an EP receptor agonist both in in vitro and in in vivo, while being more resistant to PGDH metabolism. Shown to amplify wnt activity through cAMP/PKA-mediated regulation of cellular β-catenin protein stability during vertebrate development and organ regeneration.
A cell-permeable and orally available synthetic PGE2 (Cat. No. 538904) 16,16-dimethyl derivative that exhibits similar biological activity as PGE2 as an EP receptor agonist both in in vitro and in in vivo, while being more resistant to PGDH metabolism. Shown to amplify wnt activity through cAMP/PKA-mediated regulation of cellular β-catenin protein stability during vertebrate development and organ regeneration.

Physical form

Supplied as a solution in methylacetate (1 mg/100 µL)

Preparation Note

Following reconstitution in DMSO or EtOH store at ≤-70°C for up to 6 months; Store aqueous solutions on ice and use within 12 hrs.
Gently blow away methylacetate under a stream of N2 and solubilize in either DMSO or EtOH purged with an inert gas.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Goessling, W., et al. 2009. Cell136, 1136.
Fitzgerald, J., et al. 2000. Endocrinology141, 291.
Coleman, R.A., et al. 1994. Pharmacol. Rev.46, 205.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Flammable (J)

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system

supp_hazards

EUH066

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

3.2 °F - closed cup

flash_point_c

-16 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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