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Merck

538944

U-46619

Stable thromboxane A2 mimetic and a vasoconstrictor.

Synonym(s):

U-46619, 9,11-Dideoxy-9α,11α-methanoepoxyprostaglandin F 2α

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About This Item

Empirical Formula (Hill Notation):
C21H34O4
CAS Number:
56985-40-1
Molecular Weight:
350.49
NACRES:
NA.77
UNSPSC Code:
12352211
MDL number:
MFCD00135238
Assay:
≥98% (HPLC), ≥98% (TLC)
Form:
liquid
Quality level:
100
Storage condition:
OK to freeze

Key Documents

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InChI

1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17+,18?,19+,20+/m1/s1

InChI key

LQANGKSBLPMBTJ-WTPHSRJXSA-N

assay

≥98% (HPLC), ≥98% (TLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

clear colorless

solubility

DMSO: soluble, ethanol: soluble

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

General description

Stable thromboxane A2 mimetic and a vasoconstrictor.
Stable thromboxane A2 mimetic.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Stable thromboxane A2 mimetic and a vasoconstrictor.
Product does not compete with ATP.
Reversible: no

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In methyl acetate.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C). Just prior to use, evaporate to dryness under a stream of nitrogen and dissolve in DMSO or EtOH (100 mg/ml).

Other Notes

Sametz, W., et al. 1999. Eur. J. Pharmacol. 378, 47.
Kaye, D., et al. 1997. Eur. J. Pharmacol. 340, 187.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Flammable (J)

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system

supp_hazards

EUH066

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

8.6 °F - Information refers to the main ingredient.

flash_point_c

-13 °C - Information refers to the main ingredient.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Rong Yan et al.
Cell death & disease, 12(11), 955-955 (2021-10-18)
Platelets are generated from the cytoplasm of megakaryocytes (MKs) via actin cytoskeleton reorganization. Zyxin is a focal adhesion protein and wildly expressed in eukaryotes to regulate actin remodeling. Zyxin is upregulated during megakaryocytic differentiation; however, the role of zyxin in
Serap Erdogmus et al.
Nature communications, 10(1), 5784-5784 (2019-12-21)
G-protein coupled receptors (GPCRs) are versatile cellular sensors for chemical stimuli, but also serve as mechanosensors involved in various (patho)physiological settings like vascular regulation, cardiac hypertrophy and preeclampsia. However, the molecular mechanisms underlying mechanically induced GPCR activation have remained elusive.

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