539149
Proteasome Substrate VI, Fluorogenic
A fluorogenic substrate probe useful for assaying trypsin-like activity of proteasome.
Synonym(s):
Proteasome Substrate VI, Fluorogenic, Z-ARR-AMC, 2HCl
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About This Item
Empirical Formula (Hill Notation):
C33H44N10O7 · 2HCl
CAS Number:
Molecular Weight:
765.69
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white to off-white
solubility
DMSO: 200 mg/mL, 80% acetic acid: 50 mg/mL, methanol: soluble
fluorescence
λex ~380 nm, λem ~460 nm
shipped in
ambient
storage temp.
−20°C
Quality Level
Related Categories
General description
A fluorogenic substrate for assaying trypsin-like activity of proteasome. Also serves as a substrate for cathepsin B. Excitation max: 360-380 nm; emission max.: 430-460 nm.
A fluorogenic substrate probe useful for assaying trypsin-like activity of proteasome. Also reported to be a specific substrate for cathepsin B.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Proteasome
Proteasome
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Physical form
Supplied as hydrochloride salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C
Other Notes
Geier, E., et al. 1999. Science283, 978.
Dick, T.P., et al. 1998. J. Biol. Chem. 273, 25637.
Dick, T.P., et al. 1998. J. Biol. Chem. 273, 25637.
Z-Ala-Arg-Arg-AMC
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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