539161
Proteasome Inhibitor I
InSolution, ≥90%
Synonym(s):
InSolution Proteasome Inhibitor I, PSI
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About This Item
UNSPSC Code:
12352200
Assay:
≥90% (HPLC)
Form:
liquid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Level
assay
≥90% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
storage temp.
−20°C
General description
Cell-permeable inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells. Causes the accumulation of ubiquitinated proteins in neuronal cells. Prevents NF-κB activation in response to TNFα and okadaic acid through inhibition of IκBα degradation, thereby interfering with induction of iNOS in macrophages.
Biochem/physiol Actions
Primary Target
chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells
chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells
Product does not compete with ATP.
Packaging
Packaged under inert gas
Physical form
A 50 mM (5 mg/162 µl) solution of Proteasome Inhibitor I (Cat. No. 539160) in DMSO.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Griscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 3308.
Mori, S., et al. 1995. J. Biol. Chem.270, 29447.
Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem.63, 1578.
Traenckner, E.B., et al. 1994. EMBO J.13, 5433."
Mori, S., et al. 1995. J. Biol. Chem.270, 29447.
Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem.63, 1578.
Traenckner, E.B., et al. 1994. EMBO J.13, 5433."
Z-Ile-Glu(OtBu)-Ala-Leu-CHO
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
188.6 °F - (refers to pure substance)
flash_point_c
87 °C - (refers to pure substance)
Certificates of Analysis (COA)
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