539209
Protein Arginine N-Methyltransferase Inhibitor, AMI-1
The Protein Arginine N-Methyltransferase Inhibitor, AMI-1 controls the biological activity of Protein Arginine N-Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Synonym(s):
Protein Arginine N-Methyltransferase Inhibitor, AMI-1, PRMT Inhibitor I
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About This Item
Empirical Formula (Hill Notation):
C21H12N2Na4O9S2
Molecular Weight:
592.42
NACRES:
NA.77
UNSPSC Code:
12352202
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
solubility
water: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Related Categories
General description
A cell-permeable, symmetrical sulfonated urea compound that acts as a potent, specific and non-AdoMet (S-adenosyl-L-methionine, SAM)-competitive inhibitor of protein arginine N-methyltransferases (PRMTs; IC50 = 8.81 µM for PRMT1 and 3.03 for yeast-RMT1p) with minimal effect on lysine methyltransferases. Inhibits nuclear receptor reporter gene activation in MCF-7 cells, and HIV-1 RT polymerase (IC50 = 5 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Protein arginine N-methyltransferases (PRMTs)
Protein arginine N-methyltransferases (PRMTs)
Product does not compete with ATP.
Reversible: no
Target IC50: 8.81 µM for PRMT1 and 3.03 for yeast-RMT1p
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Cheng, D., et al. 2004. J. Biol. Chem.279, 23892.
Skillman, A.G., et al. 2002. Bioorg. Chem.30, 443.
Skillman, A.G., et al. 2002. Bioorg. Chem.30, 443.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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