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Merck

539560

PKC Inhibitor Peptide 19-36

The PKC Inhibitor Peptide 19-36 controls the biological activity of PKC. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

PKC Inhibitor Peptide 19-36, Protein Kinase C Inhibitor Peptide 19-36, RFARKGALRQKNVHEVKN

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About This Item

Empirical Formula (Hill Notation):
C93H159N35O24
Molecular Weight:
2151.48
UNSPSC Code:
12352200

Key Documents

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Product Name

PKC Inhibitor Peptide 19-36, The PKC Inhibitor Peptide 19-36 controls the biological activity of PKC. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white to off-white

solubility

water: 0.1%

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: no
Primary Target
PKC
Product does not compete with ATP.
Reversible: yes
Target Ki: 147 nM against protein kinase C

Disclaimer

Toxicity: Standard Handling (A)

General description

Acts as pseudosubstrate by binding to the active sites of protein kinase C. A potent, reversible, and substrate competitive inhibitor of protein kinase C (Ki = 147 nM) but not of protein kinase A (IC50 = 423 µM).

Other Notes

H-Arg-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-Lys-Asn-Val-His-Glu-Val-Lys-Asn-OH
Makowske, M. and Rosen, O.M. 1989. J. Biol. Chem.264, 16155.
House, C. and Kemp, B.E. 1987. Science238, 1726.

Packaging

Yes

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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