PKC_β Inhibitor - CAS 257879-35-9 - Calbiochem

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of PKC_β isozymes (IC₅₀ = 5 nM and 21 nM for human PKC_βII and _βI, respectively). Displays greater selectivity for PKC_β compared to PKC_α, PKC_γ,and PKC_ε (IC₅₀ = 331 nM, >1 µM, and 2.8 µM, respectively).

An anilino-monoindolylmaleimide compound that acts as a potent, cell-permeable, reversible, and ATP-competitive inhibitor of PKC_β isozymes (IC₅₀ = 5 nM and 21 nM for human PKC_βII and _βI) and displays greater selectivity over PKC_{α, γ,& ε} (IC₅₀ = 331 nM, >1 µM, and 2.8 µM, respectively).

Cell permeable: yes

Primary Target
PKCβII, βI

Product competes with ATP.

Reversible: yes

Target IC₅₀: 5 nM, 21 nM for human PKCβII and βI

Packaged under inert gas

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Tanaka, M., et al. 2004. Bioorg. Med. Chem. Lett.14, 5171.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)