539690
Protein Synthesis Initiation Inhibitor, NSC 119889
The Protein Synthesis Initiation Inhibitor, NSC 119889 blocks 5′-mediated/cap-dependent initiation of protein synthesis. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Synonym(s):
Protein Synthesis Initiation Inhibitor, NSC 119889, 3,4,5,6-Tetrabromofluorescein
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About This Item
Empirical Formula (Hill Notation):
C20H8Br4O5
Molecular Weight:
647.89
NACRES:
NA.77
UNSPSC Code:
12352202
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
light brown
solubility
DMSO: 200 mg/mL, methanol: soluble
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5’-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
human arginine methyl transferase
human arginine methyl transferase
Product does not compete with ATP.
Reversible: no
Target IC50: 1.41 µM against human arginine methyl transferase
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Novac, O., et al. 2004. Nucleic Acids Res.32, 902.
Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol.129, 437.
Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol.129, 437.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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