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Merck

540500

Purvalanol A

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases.

Synonym(s):

Purvalanol A, 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine

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About This Item

Empirical Formula (Hill Notation):
C19H25ClN6O
CAS Number:
212844-53-6
Molecular Weight:
388.89
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD02179211

Key Documents

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Product Name

Purvalanol A, A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases.

SMILES string

Clc1cc(ccc1)Nc2nc(nc3[n](cnc32)C(C)C)N[C@@H](CO)C(C)C

InChI

1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1

InChI key

PMXCMJLOPOFPBT-HNNXBMFYSA-N

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Cdc2/cyclin B
Product does not compete with ATP.
Reversible: yes
Target IC50: 4 nM for Cdc2/cyclin B; 70 nM for Cdk2/cyclin A; 35 nM for Cdk2/cyclin E; 75 nM for Cdk5/p35

Disclaimer

Toxicity: Standard Handling (A)

General description

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC50 = 4 nM for Cdc2-cyclin B; IC50 = 70 nM for Cdk2-cyclin A; IC50 = 35 nM for Cdk2-cyclin E; and IC50 = 75 nM for Cdk5-p35).

Legal Information

Sold under license of U.S. Patents 6,617,331 and 6,803,371.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Gray, N.S., et al. 1998. Science 281, 533.

Packaging

Packaged under inert gas

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

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