Raf1 Kinase Inhibitor I

Name: Raf1 Kinase Inhibitor I
Brand: MM

InSolution, ≥97%

Synonym(s):

InSolution Raf1 Kinase Inhibitor I

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₈Br₂INO₂

Molecular Weight:

520.94

UNSPSC Code:

12352200

Product Name

Raf1 Kinase Inhibitor I, InSolution, ≥97%

assay

≥97% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

clear orange

shipped in

wet ice

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: yes

Primary Target
CRAFI kinase

Product competes with ATP.

Reversible: yes

Target IC₅₀: 9 nM against cRAF1 kinase

Disclaimer

Toxicity: Irritant (B)

General description

A potent cRaf1 kinase inhibitor (IC₅₀ = 9 nM). Shows ~100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fms. cRaf1 inhibitors are predicted to be broad spectrum anti-tumor agents.

Packaging

Packaged under inert gas

Physical form

A 10 mM (500 µg/96 µl) solution of Raf1 Inhibitor I (Cat. No. 553008) in DMSO.

Preparation Note

Following initial use, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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