553014
Raf Kinase Inhibitor IV
The Raf Kinase Inhibitor IV, also referenced under CAS 303727-31-3, controls the biological activity of Raf Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
Raf Kinase Inhibitor IV, 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole, L 779450
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About This Item
Empirical Formula (Hill Notation):
C20H14ClN3O
CAS Number:
Molecular Weight:
347.80
UNSPSC Code:
12352200
NACRES:
NA.54
MDL number:
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥97% (HPLC)
form
solid
potency
10 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
ethanol: 10 mg/mL, DMSO: 100 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
Clc1c(cc(cc1)c2nc([nH]c2c4ccncc4)c3ccccc3)O
InChI
1S/C20H14ClN3O/c21-16-7-6-15(12-17(16)25)19-18(13-8-10-22-11-9-13)23-20(24-19)14-4-2-1-3-5-14/h1-12,25H,(H,23,24)
InChI key
WXJLXRNWMLWVFB-UHFFFAOYSA-N
General description
A cell-permeable triarylimidazole compound that acts as a reversible, ATP-competitive, and highly potent inhibitor of Raf kinase (IC50 = 10 nM & Kd = 2.4 nM for B-raf) with 7-, 30-, and 70-fold selectivity over p38α, GSK-3β, and Lck, respectively. Cellular data have indicated that the compound is more effective towards Raf-1and A-Raf than B-Raf.
Biochem/physiol Actions
Cell permeable: yes
Kd = 2.4 nM for B-raf
Primary Target
Raf Kinase
Raf Kinase
Product competes with ATP.
Reversible: yes
Packaging
Packaged under inert gas
Other Notes
Takle, A.K., et al. 2006. Bioorg. Med. Chem. Lett.16, 378.
Shelton, J.G., et al. 2003. Leukemia17, 1765.
Shelton, J.G., et al. 2003. Leukemia17, 1765.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Storage Class
11 - Combustible Solids
wgk
WGK 3
Certificates of Analysis (COA)
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