Key Documents
553016
Raf Kinase Inhibitor VI
The Raf Kinase Inhibitor VI, also referenced under CAS 331444-40-7, controls the biological activity of Raf Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
Raf Kinase Inhibitor VI, 1,7-Dibenzyl-8-(2-hydroxyethylsulfanyl)-3-methyl-purine-2,6-dione
Sign Into View Organizational & Contract Pricing
Select a Size
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C22H22N4O3S
CAS Number:
Molecular Weight:
422.50
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 100 mg/mL
shipped in
wet ice
storage temp.
−20°C
General description
A purine-2,6-dione compound that targets the ATP-binding pocket of B-Raf and effectively inhibits the phosphorylation of MEK by wild-type B-Raf in cell-free in vitro kinase assays (IC50 = 1.7 µM and Ki, app = 106 nM with 100 µM ATP). Reported to be equally potent against the oncogenic V600E B-Raf mutant and exhibit much less activity against PI 3-Kγ (IC50 = 25 µM) and more than 50-fold selectivity over PAK1, GSK-3β, PAK4, MST1, and PIM1 (IC50 ≥ 100 µM).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Luo, C., et al. 2008. J. Med. Chem.51, 6121.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service