553016
Raf Kinase Inhibitor VI
The Raf Kinase Inhibitor VI, also referenced under CAS 331444-40-7, controls the biological activity of Raf Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
Raf Kinase Inhibitor VI, 1,7-Dibenzyl-8-(2-hydroxyethylsulfanyl)-3-methyl-purine-2,6-dione
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About This Item
Empirical Formula (Hill Notation):
C22H22N4O3S
CAS Number:
Molecular Weight:
422.50
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mg/mL
shipped in
wet ice
storage temp.
−20°C
General description
A purine-2,6-dione compound that targets the ATP-binding pocket of B-Raf and effectively inhibits the phosphorylation of MEK by wild-type B-Raf in cell-free in vitro kinase assays (IC50 = 1.7 µM and Ki, app = 106 nM with 100 µM ATP). Reported to be equally potent against the oncogenic V600E B-Raf mutant and exhibit much less activity against PI 3-Kγ (IC50 = 25 µM) and more than 50-fold selectivity over PAK1, GSK-3β, PAK4, MST1, and PIM1 (IC50 ≥ 100 µM).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Luo, C., et al. 2008. J. Med. Chem.51, 6121.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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