553031
RAGE Antagonist Peptide, RAP
The RAGE Antagonist Peptide, RAP controls the biological activity of RAGE.
Synonym(s):
RAGE Antagonist Peptide, RAP, ELKVLMEKEL
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About This Item
Empirical Formula (Hill Notation):
C57H101N13O17S
Molecular Weight:
1272.55
NACRES:
NA.77
UNSPSC Code:
12352111
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
powder
potency
2 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
water: 5 mg/mL
shipped in
dry ice
storage temp.
−20°C
General description
An S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.
Biochem/physiol Actions
Primary Target
RAGE
RAGE
Reversible: yes
Packaging
Packaged under inert gas
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Ac-ELKVLMEKEL-NH2
Arumugam, T., et al. 2012. Clin Cancer Res.18, 4356.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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