Skip to Content
Merck
All Photos(1)

Key Documents

553508

Sigma-Aldrich

InSolution Rac1 Inhibitor - Calbiochem

Synonym(s):

InSolution Rac1 Inhibitor - Calbiochem

Sign Into View Organizational & Contract Pricing


About This Item

Linear Formula:
C24H35N7.3HCl
UNSPSC Code:
12352200
NACRES:
NA.28

form

liquid

Quality Level

storage condition

OK to freeze

storage temp.

−20°C

General description

A cell-permeable pyrimidine compound that specifically inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~ 50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 µM). Also shown to effectively inhibit Rac1 and Rac2 activation in Lin- c-kit+ bone marrow cells stimulated with SDF-1α (effective intraperitoneal dose of 1mg/kg). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service