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Merck

555554

Rho Kinase Inhibitor IV

The Rho Kinase Inhibitor IV controls the biological activity of Rho Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

Rho Kinase Inhibitor IV, (S)-(+)-2-Methyl-4-glycyl-1-(4-methylisoquinolinyl-5-sulfonyl)homopiperazine, 2HCl, H-1152, Glycyl

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About This Item

Empirical Formula (Hill Notation):
C18H24N4O3S · 2HCl · xH2O
Molecular Weight:
449.40 (anhydrous basis)
UNSPSC Code:
12352200

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Product Name

Rho Kinase Inhibitor IV, The Rho Kinase Inhibitor IV controls the biological activity of Rho Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

pale yellow

solubility

water: 1 mg/mL
DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: yes
Primary Target
ROCK II
Product competes with ATP.
Reversible: yes
Target IC50: 11.8 nM against ROCK II

Disclaimer

Toxicity: Harmful (C)

General description

A cell-permeable, reversible, and ATP-comptetive glycyl analog of Rho-Kinase Inhibitor (Cat. No. 555550) that inhibits ROCK with an improved selectivity (IC50 = 11.8 nM, >10 µM, >10 µM, 3.26 µM, 2.35 µM, and 2.57 µM for ROCKII, PKA, PKC, PKG, Aurora A, and CaMKII, respectively).

Other Notes

Tamura, M., et al. 2005. Biochim. Biophys. Acta, 1754, 245.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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