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Merck

557305

RNAi Enhancer, Enoxacin Sodium Salt

Synonym(s):

RNAi Enhancer, Enoxacin Sodium Salt, 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid, Na salt, RNA Interference Enhancer, Enoxacin Sodium Salt

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About This Item

Empirical Formula (Hill Notation):
C15H16FN4NaO3
CAS Number:
104143-11-5
Molecular Weight:
342.30
UNSPSC Code:
12352200

Key Documents

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assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white to off-white

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Disclaimer

Toxicity: Standard Handling (A)

General description

A fluoroquinolone antibacterial compound that displays antitumor properties. Shown to bind to the miRNA biosynthesis protein TAR RNA-binding protein 2 (TRBP; Kd = 12.56 µM), enhance RNAi and stimulate miRNA expression. Specifically induces cell-cycle arrest and apoptosis in a panel of 12-cancer cells (EC50 of 124 µM in HCT-116 cells) and suppresses tumor growth in a xenograft mouse model (10 mg/kg, i.p.).

Other Notes

Melo, S., et al. 2011. Proc. Natl. Acad. Sci. USA108, 4394.
Zhang, Q., et al. 2008. Cell Res.18, 1077.
Shan, G., et al. 2008. Nat. Biotechnol.26, 933.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Francesco Greco et al.
Non-coding RNA, 9(3) (2023-06-27)
Virus-encoded microRNAs were first reported in the Epstein-Barr virus in 2004. Subsequently, a few hundred viral miRNAs have been identified, mainly in DNA viruses belonging to the herpesviridae family. To date, only 30 viral miRNAs encoded by RNA viruses are
Bidur Paudel et al.
Nature communications, 15(1), 264-264 (2024-01-19)
Alzheimer's disease (AD) is characterized by progressive neurodegeneration, but the specific events that cause cell death remain poorly understood. Death Induced by Survival gene Elimination (DISE) is a cell death mechanism mediated by short (s) RNAs acting through the RNA-induced

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