557353
RORγ Inverse Agonist, SR2211
The RORγ Inverse Agonist, SR2211 controls the biological activity of RORγ.
Synonym(s):
RORγ Inverse Agonist, SR2211, 1,1,1,3,3,3-hexafluoro-2-(2-fluoro-4′-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1′-biphenyl]-4-yl)propan-2-ol, SR-2211, SR 2211
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About This Item
Empirical Formula (Hill Notation):
C26H24F7N3O
CAS Number:
Molecular Weight:
527.48
UNSPSC Code:
12352200
MDL number:
Assay:
≥99% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥99% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
FC1=CC(C(O)(C(F)(F)F)C(F)(F)F)=CC=C1C2=CC=C(CN3CCN(CC4=CC=NC=C4)CC3)C=C2
General description
A cell-permeable, piperazine containing biphenyl compound that binds directly to retinoic acid receptor related orphan receptor γ (RORg) and acts as a highly selective and inverse agonist (Ki = 105 nM; IC50 ~ 320 nM). Reported to block the transcriptional activity of RORg and suppress the synthesis of IL-17 in EL-4 murine lymphoma cell line. Exhibits only a minimal effect on RORa and LXRa activity.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Kumar, N., et al. 2012. ACS Chem. Biol.7, 672.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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