559406
SB 328437
A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist.
Synonym(s):
SB 328437, (S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionate
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About This Item
Empirical Formula (Hill Notation):
C21H18N2O5
CAS Number:
Molecular Weight:
378.38
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
−20°C
InChI
1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
InChI key
VMFGCGRAIBLAFY-IBGZPJMESA-N
General description
A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist that acts as a high affinity, competitive inhibitor of 125I-eotaxin and 125I-MCP-4 binding to human eosinophils. Inhibits eotaxin-, eotaxin-2-, and MCP-4-mediated human eosinophil chemotaxis (IC50 = 32, 25, and 55 nM, respectively) and calcium mobilization in CCR3-transfected RBL-2H3 cells (IC50 = 38, 35, and 20 nM, respectively).
Biochem/physiol Actions
Cell permeable: no
Primary Target
CC chemokine receptor-3 (CCR3)
CC chemokine receptor-3 (CCR3)
Product does not compete with ATP.
Reversible: no
Target IC50: 38, 35, and 20 nM against calcium mobilization induced by eotaxin, eotaxin-2, or MCP-4, respectively
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
Other Notes
White, J.R., et al. 2000. J. Biol. Chem.275, 36626.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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wgk
WGK 3
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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