565000
Serine Protease Inhibitor Cocktail Set I - Calbiochem
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About This Item
NACRES:
NA.28
UNSPSC Code:
12352209
form
solid
manufacturer/tradename
(Calbiochem)
storage condition
dry at room temperature (Tightly closed)
technique(s)
inhibition assay: suitable
solubility
water: soluble
suitability
suitable for activity/function inhibition
NCBI accession no.
UniProt accession no.
application(s)
life science and biopharma
shipped in
dry ice
storage temp.
-10 to -25°C
Gene Information
human ... SERPINA(5104)
General description
The Serine Protease Inhibitor Cocktail Set I, called Serpins, is a mixture of highly specific inhibitor protein that provides a broad range of serine protease inhibition. This product specifically inhibits serine proteases using inhibitors such as 4-benzenesulfonyl fluoride hydrochloride (AEBSF), and Aprotinin.
Application
The Serine Protease Inhibitor Cocktail Set I – Calbiochem may be used:
- to protect proteins from serine protease degradation during cell or tissue lysis to preserve sample integrity.
- to maintain protein stability and native state in downstream proteomic analyses such as Western blotting, immunoprecipitation, and mass spectrometry.
- to support accurate protein quantification and characterization in studies involving biomarker discovery and post-translational modifications.
Biochem/physiol Actions
Serine proteases are enzymes involved in processes like coagulation, fibrinolysis, inflammation, apoptosis, and tissue homeostasis. It acts through complimentary and overlapping inhibitory mechanisms. Serpins like 4-Benzenesulfonyl fluoride hydrochloride (AEBSF) inhibit serine proteases by reacting rapidly with the enzyme′s catalytic serine residue. This reaction forms a stable acyl-enzyme complex that prevents protease from breaking down proteins to stop its activity.
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1A
wgk
WGK 3
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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