565610
SC-560
A cell-permeable, highly potent and selective inhibitor of COX-1 (IC50 = 9 nM).
Synonym(s):
SC-560, 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole
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About This Item
Empirical Formula (Hill Notation):
C18H12F3IN2O
CAS Number:
Molecular Weight:
456.20
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 200 mg/mL
shipped in
ambient
storage temp.
−20°C
InChI
1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
InChI key
PQUGCKBLVKJMNT-UHFFFAOYSA-N
General description
A cell-permeable, highly potent and selective inhibitor of cyclooxygenase-1 (COX-1; IC50 = 9 nM). Inhibits cyclooxygenase-2 (COX-2) only at higher concentrations (IC50 = 6.3 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
COX-1
COX-1
Product does not compete with ATP.
Reversible: no
Target IC50: 9 nM against COX-1
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Ostrom, R.S., et al. 2001. Am. J. Physiol. Cell Physiol.281, C524.
Smith, C.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13313.
Smith, C.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13313.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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